12/23/2023 0 Comments Ivinci expressIt is well known that there are many different risk factors for atherosclerosis such as high blood pressure, low-density lipoprotein (LDL) cholesterol, diabetes and smoking. Atherosclerosis as a chronic inflammatory disease of the blood vessel walls is the main potential cause of CVD. This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities.Īgeing has long been considered a major risk factor for many chronic and fatal diseases, including cardiovascular diseases (CVDs), neurodegenerative diseases and cancer. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases.
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